Features
C18 Column Series
C18 columns are the most widely used in HPLC, but every resin has its own unique characteristics.
By "endcapping" the C18 chains, an even broader range of physical and chemical properties can be achieved. High-efficiency separations result when these column properties are well balanced with those of the sample and the mobile phase.
With four different C18 chemistries, highly optimized separations can be developed.
| | C18 | C18-AQ | C18-PM | C18-NE |
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| Particle diameter(µm) | 2,3,5 | 2,3,5 | 3,5 | 5 |
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| Carbon content(%) | 16 | 12 | 22 | 17 |
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| Endcapping | Yes | Yes | Yes | No |
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| Pore diameter(nm) | 12 | 12 | 8 | 12 |
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| Features | Standard C18 column
(1)Fully endcapped for complete coverage of the silica surface.
(2)The first choice for a wide variety of analyses. | Low-Carbon C18 column
(1)Compatible with aqueous mobile phases including 100% H2O.
(2)Useful for separating highly polar compounds including saccharides, nucleic acids and organic acids. | Polymeric C18 column
(1)Usable over a wide pH range (pH 1-10).
(2)Especially useful for separating isomers and other structurally similar compounds. | Non-endcapped C18 column
(1)Unique separations are achieved as a result of the unprotected silanol |
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Additional Column Options| Product name | Features | Carbon content (%) |
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| LaChrom C8 (5µm) | Useful for separating highly hydrophobic compounds as their strength of interaction with the resin is reduced (compared to C18). A reduction in analysis time is also realized. | 10 |
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| LaChrom Ph (5µm) | The phenyl group modifier is useful for separating aromatic compounds based on pai-electron interactions. | 9 |
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| LaChrom CN (5µm) | The cyano group modifier can be employed in both reverse and normal phase separations. Its unique selectivity is useful for separating extremely hydrophobic compounds (reversed phase) or based on polar interactions (normal phase). | 7 |
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| LaChrom SIL (5µm) | The first choice for normal phase separations. It can be used for separating fat-soluble compounds or positional isomers, for example which are difficult or impossible to separate in reverse phase systems. | - |
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| LaChrom Diol (5µm) | Separation is based on the interaction with hydroxyl groups. This distinctive column chemistry can be used in both HILIC (hydrophilic interaction chromatography) and normal phase applications. | - |
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| LaChrom NH2 (5µm) | The advanced surface modification of this amino phase exhibits excellent durability and is particularly useful for analyzing saccharides and oligosaccharides. | - |
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